Azelnidipine Impurity 4(CAS: 170749-59-4)

Azelnidipine Impurity 4 is a crystalline solid with a molecular weight of approximately 438.49 g/mol. It has a low solubility in water but is more soluble in organic solvents like methanol and ethanol. Chemically, it shows limited reactivity under normal conditions but can undergo hydrolysis in the presence of strong acids or bases.

Azelnidipine Impurity 4 is synthesized through a multi-step process involving acylation and cyclization reactions. The key steps include the introduction of a functional group followed by ring formation, yielding the impurity with a high degree of purity and selectivity. The overall yield is around 85%, with the use of mild conditions to achieve a clean product.

Azelnidipine Impurity 4 is primarily used in the pharmaceutical industry as an intermediate in the synthesis of azelnidipine, a calcium channel blocker used in the treatment of hypertension and angina. It is also relevant in research and development for pharmaceutical and chemical companies.

When handling Azelnidipine Impurity 4, it is important to use personal protective equipment (PPE) such as gloves, a lab coat, and safety goggles. Work in a well-ventilated area or fume hood to avoid inhalation. Proper spill containment and disposal procedures should be followed. Refer to the Safety Data Sheet (SDS) for detailed instructions and emergency response guidelines.