3H-Imidazo[4,5-b]pyridine-7-carboxylic acid(CAS: 78316-08-2)

3H-Imidazo[4,5-b]pyridine-7-carboxylic acid (CAS: 78316-08-2) is a crystalline solid with a molecular weight of approximately 216.17 g/mol. It has a pKa of about 4.4, indicating a weak acidic nature. The compound is poorly soluble in water but soluble in organic solvents like methanol and ethanol. It is relatively stable under normal conditions but can react with bases to form salts.

3H-Imidazo[4,5-b]pyridine-7-carboxylic acid can be synthesized through multistep reactions starting with pyridine and imidazole. One common approach involves the reaction of imidazole with 4-bromopyridine followed by hydrolysis. The yield is around 70%, and the purity can be increased through recrystallization.

3H-Imidazo[4,5-b]pyridine-7-carboxylic acid is used in the pharmaceutical industry as a precursor for drug synthesis. It is also utilized in the polymer industry for the development of advanced materials and in the electronics industry for the fabrication of semiconductors and sensors due to its electronic properties.

When handling 3H-Imidazo[4,5-b]pyridine-7-carboxylic acid, it is important to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated fume hood to minimize exposure. Spills should be cleaned up with caution, ideally using absorbent material followed by thorough rinsing. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions.