4-[(methylamino)methyl]quinolin-2-ol(CAS: 716342-80-2)

4-[(methylamino)methyl]quinolin-2-ol is a solid with a crystalline form. Its molecular weight is approximately 220.29 g/mol. It has a low water solubility and is moderately soluble in organic solvents. It is relatively stable under normal conditions but can react with strong acids. It shows good reactivity towards nucleophiles and has potential as a chiral ligand in catalysis.

4-[(methylamino)methyl]quinolin-2-ol is typically synthesized via a multistep process involving the condensation of 2-aminobenzaldehyde with methylamine followed by amination. The reaction is performed under basic conditions using potassium carbonate as a catalyst. The overall yield is around 80%, and the method offers good selectivity for the desired product.

4-[(methylamino)methyl]quinolin-2-ol finds applications in the pharmaceutical industry as a chiral ligand in catalytic reactions and as a precursors in organic synthesis. It is also used in the polymer industry for its reactive functional groups and in the sensing industry for its optical properties.

When handling 4-[(methylamino)methyl]quinolin-2-ol, it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood. Spills should be contained and cleaned up with appropriate absorbents. Always refer to the safety data sheet (SDS) for detailed handling and disposal instructions.