N-Cbz-guanidine(CAS: 16706-54-0)

N-Cbz-guanidine is a white crystalline solid with a molecular weight of approximately 301.32 g/mol. It is sparingly soluble in water but soluble in organic solvents like methanol and ethanol. Chemically, it exhibits basic properties and is relatively stable under normal conditions but can react with acids to form salts.

N-Cbz-guanidine is synthesized by the amidation of guanidine with p-chlorobenzyl chlorides. This reaction is typically catalyzed by a phase-transfer catalyst and proceeds with good yield. The product is then purified by recrystallization from appropriate solvents.

N-Cbz-guanidine is primarily used in the pharmaceutical industry for the synthesis of various bioactive compounds. It is also utilized in polymer science for the modification of polymer properties and in sensor technology for its specific reactivity with certain functional groups.

When handling N-Cbz-guanidine, it is important to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up immediately with appropriate absorbents and the area should be thoroughly washed. Refer to the Safety Data Sheet (SDS) for specific handling and disposal instructions.