3-Acetamido-5-methoxybenzoic acid(CAS: 78238-03-6)

3-Acetamido-5-methoxybenzoic acid is a white crystalline solid with a molecular weight of approximately 224.17 g/mol. It has a pKa of about 4.1 and is moderately soluble in water. The compound is reactive towards nucleophiles and can undergo substitution reactions. It is slightly soluble in common organic solvents like ethanol and acetone.

3-Acetamido-5-methoxybenzoic acid is typically synthesized via the acetylation of 5-methoxybenzoic acid followed by the amide coupling reaction. The synthesis involves the use of acetic anhydride and a suitable base such as pyridine. The yield is generally around 80-85%, and the reaction is carried out with good selectivity.

3-Acetamido-5-methoxybenzoic acid is used in the pharmaceutical industry for the synthesis of certain drugs. It is also employed in the polymer industry as a monomer in the production of various polymers. Additionally, it finds applications in the development of sensors and in semiconductor materials due to its specific chemical properties.

When handling 3-Acetamido-5-methoxybenzoic acid, it is important to use personal protective equipment (PPE) such as gloves, goggles, and a laboratory coat. The compound should be handled in a well-ventilated area or a fume hood. Spills should be cleaned up using absorbent materials and disposed of according to local regulations. Always refer to the safety data sheet (SDS) for detailed safety information.