3-Chloro-5-(Trifluoromethyl)Pyridine-2-Carboxylic Acid(CAS: 80194-18-9)

3-Chloro-5-(Trifluoromethyl)Pyridine-2-Carboxylic Acid is a crystalline solid with a molecular weight of approximately 279.05 g/mol. It has a high solubility in organic solvents such as DMSO and DMF. Chemically, it is reactive towards nucleophiles and can participate in nucleophilic substitution reactions. It is often used in pharmaceutical and polymer synthesis due to its unique electronic properties.

3-Chloro-5-(Trifluoromethyl)Pyridine-2-Carboxylic Acid is typically synthesized via a multistep process involving acylation of pyridine derivatives. Commonly, acetic anhydride or acetyl chloride is used as the acylating agent, followed by chlorination and trifluoromethylation steps. High yield and high selectivity are achieved using appropriate catalysts and reaction conditions.

3-Chloro-5-(Trifluoromethyl)Pyridine-2-Carboxylic Acid is widely used in pharmaceuticals for drug synthesis, particularly in the development of anti-inflammatory and antiviral compounds. It is also utilized in the polymer industry for the production of advanced materials and in the development of sensitive chemical sensors.

When handling 3-Chloro-5-(Trifluoromethyl)Pyridine-2-Carboxylic Acid, it is essential to wear gloves, protective goggles, and a lab coat. Work should be conducted in a well-ventilated area or within a fume hood. Spills should be cleaned up using appropriate absorbent materials. Always consult the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.