1-(2-(Di-tert-butylphosphino)phenyl)-3,5-diphenyl-1H-pyrazole(CAS: 628333-86-8)

1-(2-(Di-tert-butylphosphino)phenyl)-3,5-diphenyl-1H-pyrazole is a solid with a crystalline form. Its molecular weight is approximately 662.48 g/mol. The compound is slightly soluble in common organic solvents. It is relatively stable under normal conditions but can react with strong oxidizing agents. The compound has been observed to have good thermal stability up to 300°C.

1-(2-(Di-tert-butylphosphino)phenyl)-3,5-diphenyl-1H-pyrazole is typically synthesized via a multistep process involving the coupling of 2-(di-tert-butylphosphino)phenylboronic acid and 3,5-diphenylpyrazole. The synthesis often utilizes palladium catalysts and is carried out in the presence of a base such as potassium carbonate. The overall yield is generally around 60-80%, with excellent selectivity towards the target product.

1-(2-(Di-tert-butylphosphino)phenyl)-3,5-diphenyl-1H-pyrazole finds applications in pharmaceuticals and as a ligand in catalysis. It is used as a chelating agent and as an organophosphorus compound in various synthetic processes. Additionally, it has potential uses in sensors and as a stabilizer in polymer formulations.

When handling 1-(2-(Di-tert-butylphosphino)phenyl)-3,5-diphenyl-1H-pyrazole, it is advisable to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. The compound should be handled in a well-ventilated area or under a fume hood. Spills should be cleaned up immediately using appropriate absorbent materials. Refer to the Safety Data Sheet (SDS) for detailed instructions and safety information.