1,4,7,10,13-Pentaoxa-16-azacyclooctadecane(CAS: 33941-15-0)

1,4,7,10,13-Pentaoxa-16-azacyclooctadecane is a colorless solid with a molecular weight of approximately 272.31 g/mol. It has a low solubility in water but is soluble in common organic solvents. It exhibits limited reactivity under normal conditions but can undergo ring-opening reactions under basic conditions. It is a chiral compound with a melting point of 115-117°C.

1,4,7,10,13-Pentaoxa-16-azacyclooctadecane can be synthesized via a ring-closing metathesis of a cyclic diol or via a Wittig reaction pathway. Commonly, a Wittig reaction of a suitable aldehyde or ketone with a phosphorane followed by aqueous acid work-up is used. The product is obtained with good yield and selectivity.

1,4,7,10,13-Pentaoxa-16-azacyclooctadecane is used in the pharmaceutical industry for the synthesis of certain drugs, in polymer chemistry for the production of special polymers, and in the manufacturing of sensors and semiconductors due to its unique molecular structure.

When handling 1,4,7,10,13-Pentaoxa-16-azacyclooctadecane, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up immediately using appropriate methods, and safety data sheets (SDS) should be consulted for detailed handling instructions. Storage should be in a cool, dry place, away from direct sunlight and ignition sources.