(4R)-1-[(Benzyloxy)carbonyl]-4-hydroxy-L-proline(CAS: 13504-85-3)

(4R)-1-[(Benzyloxy)carbonyl]-4-hydroxy-L-proline is a white crystalline solid. Its molecular weight is approximately 300.36 g/mol. It is poorly water-soluble but soluble in organic solvents. This compound exhibits moderate reactivity, particularly towards nucleophilic attack at the hydroxyl group.

(4R)-1-[(Benzyloxy)carbonyl]-4-hydroxy-L-proline is synthesized by the condensation of benzyloxycarbonyl chloride with (4R)-4-hydroxy-L-proline. This reaction is catalyzed by triethylamine in dichloromethane. The product is purified by column chromatography, yielding a high yield of 80-85%.

(4R)-1-[(Benzyloxy)carbonyl]-4-hydroxy-L-proline is primarily used in pharmaceuticals for the synthesis of biologically active compounds. It also finds applications in the production of polymers and as a precursor in the development of new materials for sensors and semiconductors.

Proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn when handling (4R)-1-[(Benzyloxy)carbonyl]-4-hydroxy-L-proline. It should be stored in a cool, dry place, away from direct sunlight and sources of heat. In case of spill, it should be cleaned up using appropriate procedures and materials. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.