4-Nitrophthalamide(CAS: 13138-53-9)

4-Nitrophthalamide (CAS: 13138-53-9) is a white crystalline solid. Its molecular weight is approximately 238.07 g/mol. It is slightly soluble in water but more soluble in organic solvents like ethanol and acetone. Chemically, it is reactive towards nucleophiles and can undergo substitution reactions. It has a melting point of about 100-102°C and a boiling point of around 230-235°C. It is a stable compound under normal conditions but should be handled with care due to its reactivity.

4-Nitrophthalamide (CAS: 13138-53-9) is typically synthesized by the nitration of phthalamide using nitric acid and sulfuric acid as catalysts. The nitration process usually yields 90-95% purity. The product can be purified by recrystallization from ethanol or acetone. This synthesis method is well-documented in the literature and is known for its high yield and good selectivity.

4-Nitrophthalamide (CAS: 13138-53-9) finds applications in various industries, including pharmaceuticals, where it serves as an intermediate in the synthesis of other nitrogen-containing compounds. It is also used in the production of dyes and pigments. Additionally, it has potential uses in polymer chemistry and as a reagent in analytical chemistry for developing sensors and semiconductors.

When handling 4-Nitrophthalamide (CAS: 13138-53-9), it is important to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up immediately using appropriate absorbents and handled according to the safety data sheet (SDS). The compound should be stored in a cool, dry place away from heat sources and incompatible materials. Always consult the SDS for detailed handling and storage instructions.