7-Hydroxy-4-(trifluoromethyl)-2H-chromen-2-one(CAS: 575-03-1)

7-Hydroxy-4-(trifluoromethyl)-2H-chromen-2-one is a crystalline solid with a molecular weight of 279.06 g/mol. It is sparingly soluble in water but more soluble in organic solvents such as ethanol and acetone. Chemically, it shows strong reactivity towards nucleophiles and can undergo various transformations such as reduction and substitution reactions.

7-Hydroxy-4-(trifluoromethyl)-2H-chromen-2-one is commonly synthesized via Friedel-Crafts acylation of chromone derivatives with trifluoromethyl ketones under the use of Lewis acids like aluminum chloride. The reaction is typically conducted in dichloromethane or ethyl acetate, with high yield and good selectivity.

7-Hydroxy-4-(trifluoromethyl)-2H-chromen-2-one is primarily used in the pharmaceutical industry for its potential as an intermediate in drug synthesis. It also finds applications in the polymer industry for its ability to act as a monomer, and in the semiconductor industry as a dopant material.

When handling 7-Hydroxy-4-(trifluoromethyl)-2H-chromen-2-one, it is important to wear appropriate personal protective equipment (PPE) such as gloves and goggles. Work should be conducted in a well-ventilated fume hood. In case of a spill, use appropriate spill cleanup materials and follow local safety regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling information.