Compound Q&A
How is 7-Hydroxy-4-(trifluoromethyl)-2H-chromen-2-one (CAS: 575-03-1) typically synthesized?
Answer
7-Hydroxy-4-(trifluoromethyl)-2H-chromen-2-one is commonly synthesized via Friedel-Crafts acylation of chromone derivatives with trifluoromethyl ketones under the use of Lewis acids like aluminum chloride. The reaction is typically conducted in dichloromethane or ethyl acetate, with high yield and good selectivity.
About
CAS No
575-03-1
English Name
7-Hydroxy-4-(trifluoromethyl)-2H-chromen-2-one
Molecular Formula
C10H5F3O3
Molecular Weight
230.14099999999996 g/mol
SMILES
C1=CC2=C(C=C1O)OC(=O)C=C2C(F)(F)F
InChIKey
CCKWMCUOHJAVOL-UHFFFAOYSA-N
Last Updated: 2025-10-17 07:35
