Luminespib(CAS: 747412-49-3)

Luminespib (CAS: 747412-49-3) is a small molecule with a molecular weight of approximately 429.26 g/mol. It crystallizes in the orthorhombic system and has a solubility of 15 μg/mL in DMSO. Luminespib is relatively stable but can undergo hydrolysis under basic conditions. It is a potent inhibitor of the WDR5 protein, which makes it particularly interesting for research purposes.

Luminespib (CAS: 747412-49-3) is synthesized through a complex multistep process involving a Michael addition followed by a ring closure. The key steps require careful control of pH and temperature to achieve high yields and selectivity. The synthesis typically involves the use of 1,3-dipolar cycloaddition reactions and subsequent functional group manipulations.

Luminespib (CAS: 747412-49-3) is primarily used in the pharmaceutical industry for its potential as a WDR5 inhibitor. It has applications in cancer research and drug discovery. Additionally, it can be used in research settings for studying histone methyltransferases. Its other potential applications include use in sensor technologies and as a tool compound in synthetic chemistry.

When handling Luminespib (CAS: 747412-49-3), it is important to use proper Personal Protective Equipment (PPE) such as gloves, goggles, and lab coats. Work should be conducted in a well-ventilated fume hood to minimize exposure. Spills should be cleaned up carefully following appropriate guidelines, and the material should be disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and safety information.