Bruceantinol(CAS: 53729-52-5)

Bruceantinol (CAS: 53729-52-5) is a white to off-white crystalline powder. Its molecular weight is approximately 281.33 g/mol. It is slightly soluble in water and has limited solubility in organic solvents. Chemically, it is stable under normal conditions but reacts with strong oxidizers. It is a chiral compound with enantiomeric forms.

Bruceantinol is typically synthesized through asymmetric reduction of a ketone using a chiral catalyst such as (S)-()-phenylglycinol hydrochloride. The reaction conditions include the use of lithium triisopropylsilyl ether as a protecting group. The yield is around 75%, and the enantiomeric excess (ee) can be controlled to achieve high purity.

Bruceantinol is used in the pharmaceutical industry for the synthesis of chiral drugs. It is also utilized in the polymer industry as a chiral building block for producing enantioselective polymers. Additionally, it is used in the sensor industry for developing chiral sensors and in semiconductor manufacturing for enantioselective lithography processes.

When handling Bruceantinol, use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood. Store it in a tightly sealed container away from strong oxidizers. In case of a spill, clean up with care, ensuring the area is properly ventilated. Refer to the Safety Data Sheet (SDS) for detailed emergency procedures and storage recommendations.