(5-Amino-3-pyridinyl)boronic acid(CAS: 1169748-84-8)

(5-Amino-3-pyridinyl)boronic acid is a crystalline compound with a molecular weight of approximately 211.2 g/mol. It is slightly soluble in water and ethanol. This compound exhibits moderate reactivity, particularly in nucleophilic substitution reactions. It is stable under normal conditions but should be stored in a dry, cool place away from direct sunlight.

(5-Amino-3-pyridinyl)boronic acid is commonly synthesized via the reaction of 3-bromopyridine with boronic acid in the presence of a catalyst such as palladium(II) acetate and a base like triethylamine. This method provides good selectivity and yield, making it a reliable synthesis route.

(5-Amino-3-pyridinyl)boronic acid is utilized in various industries due to its functional groups. It is particularly important in pharmaceuticals for the synthesis of drug intermediates, in polymers for functionalization, and in sensors for detection purposes. Its role in semiconductors is also recognized for its ability to form stable complexes.

When handling (5-Amino-3-pyridinyl)boronic acid, it is essential to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. Work in a well-ventilated area or fume hood to prevent inhalation. In the case of a spill, immediately clean up with appropriate absorbent materials and dispose of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage instructions.