4-[2-(Trifluoromethyl)phenoxy]piperidine(CAS: 824390-04-7)

4-[2-(Trifluoromethyl)phenoxy]piperidine is a white crystalline solid with a molecular weight of approximately 323.14 g/mol. It is slightly soluble in water but soluble in organic solvents such as ethanol and chloroform. Chemically, it is relatively stable but can react with strong acids to form less stable derivatives. The compound has a pKa of around 7.5 and is known for its potent agonist activity at muscarinic receptors.

4-[2-(Trifluoromethyl)phenoxy]piperidine is synthesized via a multistep procedure involving the protection of a piperidine ring, followed by introduction of the trifluoromethyl group, and finally deprotection. Commonly used reagents include trifluoromethyl chlorides, protecting agents like tert-butyldiphenylsilyl chloride, and various protecting and deprotecting strategies. The overall yield can range from 50-70%, depending on the purification and reaction conditions.

4-[2-(Trifluoromethyl)phenoxy]piperidine is primarily used in the pharmaceutical industry for developing muscarinic receptor agonists. It also finds applications in sensors and as a research tool in medicinal chemistry. Due to its chemical stability and biological activity, it is a valuable compound in the development of new drugs and in understanding receptor interactions.

When handling 4-[2-(Trifluoromethyl)phenoxy]piperidine, ensure the use of personal protective equipment (PPE) such as gloves and goggles. Work in a fume hood to minimize exposure. Store the compound in a cool, dry place away from incompatible materials. In case of spill, neutralize the spill with a suitable reagent and dispose of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling instructions.