Pyrrolidine-2-carbonitrile hydrochloride(CAS: 1199773-80-2)

Pyrrolidine-2-carbonitrile hydrochloride (CAS: 1199773-80-2) is a crystalline solid with a molecular weight of approximately 158.63 g/mol. It has a pKa of around 2.8 and is slightly soluble in water. This compound is less reactive compared to other nitriles but can undergo nucleophilic substitution reactions. It has a low melting point and is stable under normal conditions.

Pyrrolidine-2-carbonitrile hydrochloride is commonly synthesized via the reaction of pyrrolidine-2-carbonitrile with hydrochloric acid. The synthesis involves the addition of HCl to the nitrile group, leading to the formation of the hydrochloride salt. The process is conducted at room temperature and under mild conditions to ensure high yield and selectivity.

Pyrrolidine-2-carbonitrile hydrochloride (CAS: 1199773-80-2) is used in various industries, including pharmaceuticals, where it serves as a precursor for the synthesis of certain drugs. It also finds applications in the production of sensors and semiconductors, where its unique chemical properties are utilized.

When handling Pyrrolidine-2-carbonitrile hydrochloride (CAS: 1199773-80-2), it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a laboratory coat. Work should be conducted in a well-ventilated area or fume hood to avoid inhalation of the compound. Spills should be cleaned up using appropriate procedures, and the safety data sheet (SDS) should be consulted for specific handling instructions.