N-(2-Methyl-2-propanyl)-1H-indazole-7-carboxamide(CAS: 1476776-76-7)

N-(2-Methyl-2-propanyl)-1H-indazole-7-carboxamide (CAS: 1476776-76-7) is a solid crystalline compound with a molecular weight of approximately 266.34 g/mol. It is soluble in solvents like dimethylformamide (DMF) and acetonitrile. The compound is moderately reactive, particularly under acidic conditions. It exhibits good thermal stability up to 250°C and has a pKa of around 4.0. Its high solubility and reactivity make it suitable for various chemical reactions.

N-(2-Methyl-2-propanyl)-1H-indazole-7-carboxamide is usually synthesized through a multi-step process involving the condensation of indazole-7-carboxylic acid with 2-methyl-2-propanamine. The reaction typically occurs in the presence of a coupling agent like 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) and N-hydroxysuccinimide (NHS). The yield can be as high as 85% under optimized conditions, and the product is isolated by recrystallization from a suitable solvent.

N-(2-Methyl-2-propanyl)-1H-indazole-7-carboxamide is used in pharmaceuticals for developing new drug candidates due to its potential as an inhibitor of certain enzymes. It also finds applications in the semiconductor industry as a precursor for the synthesis of organic semiconductors. Additionally, it is explored in the polymer and sensor industries for its reactivity and solubility properties.

When handling N-(2-Methyl-2-propanyl)-1H-indazole-7-carboxamide (CAS: 1476776-76-7), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and laboratory coats. Work should be conducted in a well-ventilated area or fume hood to minimize exposure. Spills should be cleaned up immediately using absorbent materials and appropriately disposed of. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures.