4-fluorobenzene-1-carboximidamide(CAS: 2339-59-5)

4-Fluorobenzene-1-carboximidamide (CAS: 2339-59-5) is a solid white crystalline compound with a molecular weight of approximately 174.04 g/mol. It is slightly soluble in water and more soluble in organic solvents like ethanol and acetone. The compound is known for its reactivity, particularly in nucleophilic substitution reactions. It is stable under normal conditions but reacts readily with bases and reducing agents.

4-Fluorobenzene-1-carboximidamide (CAS: 2339-59-5) can be synthesized through the acylation of 4-fluorobenzenesulfonamide with acyl halides in the presence of a base. This method provides high yield and good selectivity. Commonly used catalysts include sodium hydride and triethylamine. The reaction is typically carried out in anhydrous solvents such as dimethylformamide (DMF) or N,N-dimethylacetamide (DMAc) under mild conditions.

4-Fluorobenzene-1-carboximidamide (CAS: 2339-59-5) is primarily used in the pharmaceutical industry for the synthesis of various drugs. It is also employed in the polymer industry for the modification of polymers, and in the sensor industry for the development of chemical sensors. Additionally, it finds applications in the semiconductor industry for the production of electronic materials.

When handling 4-fluorobenzene-1-carboximidamide (CAS: 2339-59-5), it is essential to use appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. The compound should be handled in a well-ventilated area or under a fume hood. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. A Safety Data Sheet (SDS) should be consulted for detailed handling and storage information.