2-Phenylimidazo[1,2-a]pyridine(CAS: 4105-21-9)

2-Phenylimidazo[1,2-a]pyridine is a crystalline solid with a molecular weight of approximately 182.21 g/mol. It is slightly soluble in water but more soluble in organic solvents like ethanol and acetone. Chemically, it is moderately reactive towards nucleophiles and exhibits good stability under normal conditions. It is also known to have some photochemical and electrochemical properties.

2-Phenylimidazo[1,2-a]pyridine is typically synthesized via the condensation of 2-bromopyridine and aniline using a suitable base like sodium hydride as a catalyst. The reaction proceeds under mild conditions, yielding a product with high selectivity. The overall yield is around 70-80%.

2-Phenylimidazo[1,2-a]pyridine finds applications in the pharmaceutical industry as a potential anti-inflammatory agent and in the polymer industry as a stabilizer. It is also used in the development of sensors and as a precursor for organic electronics and semiconductors.

When handling 2-Phenylimidazo[1,2-a]pyridine, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up using appropriate absorbents and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.