4-Chloro-3-cyanopyridine(CAS: 89284-61-7)

4-Chloro-3-cyanopyridine is a crystalline solid with a molecular weight of approximately 169.57 g/mol. It has a solubility of around 100 mg/L in water and is sparingly soluble in ethanol and acetone. Chemically, it is moderately reactive, showing electrophilic aromatic substitution and nucleophilic addition properties.

4-Chloro-3-cyanopyridine is typically synthesized via the cyanation of 4-chloropyridine. This process involves the use of copper iodide as a catalyst, providing good yield and selectivity. The reaction is usually carried out in an inert atmosphere and at controlled temperatures to ensure optimal reaction conditions.

4-Chloro-3-cyanopyridine is primarily used in the pharmaceutical industry for the synthesis of certain drugs. It is also utilized in the polymer industry for the production of special plastics and in the semiconductor industry for photoresists. Additionally, it finds applications in the development of sensors and as a precursor for other chemical compounds.

When handling 4-Chloro-3-cyanopyridine, it is essential to wear appropriate personal protective equipment (PPE) such as gloves and goggles. The substance should be handled in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbent materials, and the area should be ventilated. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.