1'-(2-Methylalanyl-O-benzyl-D-seryl)-1-(methylsulfonyl)-1,2-dihydrospiro[indole-3,4'-piperidine] methanesulfonate (1:1)(CAS: 159752-10-0)

1'-(2-Methylalanyl-O-benzyl-D-seryl)-1-(methylsulfonyl)-1,2-dihydrospiro[indole-3,4'-piperidine] methanesulfonate is a crystalline compound with a molecular weight around 730 g/mol. It is poorly soluble in water but soluble in organic solvents such as DMSO and DMF. The compound shows moderate reactivity, particularly towards nucleophilic substitution reactions. It can be isolated as a dihydrate form with a melting point of 180-182°C.

This compound can be synthesized by reacting benzyl esters of D-seryl chlorides with 2-methylalanyl-O-benzyl chloride in the presence of a catalytic amount of a base such as triethylamine. The reaction is typically carried out in an anhydrous organic solvent like DMF or DCM. The product is isolated by column chromatography, and the methanesulfonate ester is formed by treating the product with methanesulfonyl chloride in the presence of a base like sodium hydride.

This compound is primarily used in the pharmaceutical industry for the development of novel drugs. It may also find applications in the polymer industry for the synthesis of advanced materials. Additionally, it could be used in the sensor industry for developing biosensors due to its chemical reactivity and structural complexity.

When handling this compound, it is essential to use personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to avoid inhalation of vapors. Spills should be cleaned up with caution using appropriate absorbent materials. Always refer to the safety data sheet (SDS) for detailed handling instructions and emergency response procedures.