Ethyl 4-ethynylbenzoate(CAS: 10602-03-6)

Ethyl 4-ethynylbenzoate (CAS: 10602-03-6) is a crystalline solid with a molecular weight of approximately 160.22 g/mol. It is poorly soluble in water but soluble in organic solvents such as ethanol and acetone. Chemically, it is less reactive than other similar compounds due to the presence of the vinyl group, which can participate in electrophilic addition reactions.

Ethyl 4-ethynylbenzoate is typically synthesized via the Grignard reaction. Ethyl magnesium bromide reacts with benzoic anhydride to form the desired product. The reaction is carried out in anhydrous ether, and the yield can be improved by using high-purity reagents and maintaining an inert atmosphere.

Ethyl 4-ethynylbenzoate (CAS: 10602-03-6) is used in the pharmaceutical industry for the synthesis of certain drugs due to its ethynyl group, which can participate in bioorthogonal reactions. It is also utilized in the polymer industry for the preparation of novel materials with specific properties.

When handling Ethyl 4-ethynylbenzoate (CAS: 10602-03-6), ensure that you wear appropriate personal protective equipment, including gloves and safety goggles. Work in a well-ventilated area or fume hood to minimize exposure. Keep the compound away from heat and ignition sources. In case of a spill, handle it according to the Material Safety Data Sheet (SDS) guidelines.