2,3,4-Trifluorobenzonitrile(CAS: 143879-80-5)

2,3,4-Trifluorobenzonitrile (CAS: 143879-80-5) is a colorless to light yellow liquid. It has a boiling point of 173.9°C and a melting point of -16.6°C. The molecular weight is 178.09 g/mol. It is slightly soluble in water but miscible with most organic solvents. This compound is known for its reactivity with nucleophiles and electrophiles, making it useful in various synthetic transformations.

2,3,4-Trifluorobenzonitrile (CAS: 143879-80-5) can be synthesized via alkylation of 2,3,4-trifluorobenzoic acid with hydrogen cyanide. Commonly, a phase-transfer catalyst is used to improve yield and selectivity. The reaction typically occurs at elevated temperatures and involves the formation of an intermediate salt that is further converted to the nitrile.

2,3,4-Trifluorobenzonitrile (CAS: 143879-80-5) is primarily used in the pharmaceutical and polymer industries for the synthesis of medicinals and plastics. It is also applied in the production of sensors and semiconductors due to its unique chemical properties.

When handling 2,3,4-Trifluorobenzonitrile (CAS: 143879-80-5), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Store it in a fume hood to minimize exposure to fumes. In case of a spill, immediately evacuate the area and follow the emergency procedures outlined in the Safety Data Sheet (SDS). This compound is flammable and may release toxic fumes upon contact with water or air, so avoid inhaling vapors and handle it with care.