ethyl 4-amino-2-chloro-pyrimidine-5-carboxylate(CAS: 71406-78-5)

Ethyl 4-amino-2-chloro-pyrimidine-5-carboxylate (CAS: 71406-78-5) is a crystalline solid with a molecular weight of approximately 254.7 g/mol. It has a low solubility in water but dissolves well in organic solvents such as ethanol and chloroform. The compound exhibits moderate reactivity, particularly towards nucleophiles, and is stable under acidic and basic conditions. It is often used as a precursor in organic synthesis.

Ethyl 4-amino-2-chloro-pyrimidine-5-carboxylate (CAS: 71406-78-5) is synthesized via the reaction of 2-chloropyrimidine-5-carboxylic acid with ethylamine in the presence of a catalytic amount of an acid or base. The reaction yields a high purity product with a yield of over 90%. The process involves the nucleophilic substitution of the carboxylic acid group by the amino group from ethylamine.

Ethyl 4-amino-2-chloro-pyrimidine-5-carboxylate (CAS: 71406-78-5) is primarily used in the pharmaceutical industry as an intermediate in the synthesis of drugs. It also finds application in the development of novel materials for sensors and semiconductors. Its versatility in organic synthesis makes it a valuable compound for researchers in various scientific fields.

When handling ethyl 4-amino-2-chloro-pyrimidine-5-carboxylate (CAS: 71406-78-5), it is essential to wear appropriate personal protective equipment (PPE), including gloves and safety glasses. The compound should be stored in a cool, dry place away from direct sunlight and flammable materials. In case of a spill, immediately clean up with appropriate absorbents and dispose of according to local regulations. Always consult the Material Safety Data Sheet (MSDS) for detailed handling instructions and emergency procedures.