4-Amino-2-fluorobenzoic acid(CAS: 446-31-1)

4-Amino-2-fluorobenzoic acid (CAS: 446-31-1) is a white crystalline solid with a molecular weight of approximately 187.03 g/mol. It is slightly soluble in water and has a pKa of about 4.1. The compound shows moderate reactivity, particularly with strong acids and bases. It is often used in organic synthesis due to its functional groups.

4-Amino-2-fluorobenzoic acid (CAS: 446-31-1) can be synthesized via a multi-step process involving the fluorination of benzoic acid followed by aminoation. Common methods include the use of fluorine gas in the presence of a Lewis acid catalyst, followed by reaction with an amine in the presence of a suitable base. The yield and selectivity can be enhanced by optimizing reaction conditions.

4-Amino-2-fluorobenzoic acid (CAS: 446-31-1) is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It also finds applications in the production of dyes and pigments, as well as in materials science for its unique chemical properties.

When handling 4-Amino-2-fluorobenzoic acid (CAS: 446-31-1), it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. The compound should be stored in a cool, dry place away from direct sunlight and heat sources. In case of a spill, dispose of it according to safety data sheet (SDS) guidelines and ensure proper ventilation during handling.