Ethyl 1H-pyrazol-3-ylacetate(CAS: 82668-50-6)

Ethyl 1H-pyrazol-3-ylacetate is a colorless to white crystalline solid with a molecular weight of approximately 216.24 g/mol. It has a pKa of around 4.3, indicating it is slightly acidic. The compound is soluble in organic solvents such as ethanol and acetone but has low solubility in water. It is known for its reactivity towards nucleophiles and can undergo nucleophilic substitution reactions.

Ethyl 1H-pyrazol-3-ylacetate can be synthesized via the condensation of 1H-pyrazol-3-yl acetic acid and ethylamine. This reaction typically occurs under mild conditions, utilizing an appropriate solvent such as tetrahydrofuran (THF) or acetonitrile. The yield can be increased by using a catalytic amount of a Lewis acid like aluminum chloride to improve the reaction selectivity and conversion rate.

Ethyl 1H-pyrazol-3-ylacetate is primarily used in the pharmaceutical industry for the synthesis of various medicinal compounds, particularly those involving heterocyclic systems. It is also utilized in the polymer industry as a monomer or modifier. Additionally, it can be employed in the development of chemical sensors and as an intermediate in the semiconductor industry due to its unique chemical properties.

When handling Ethyl 1H-pyrazol-3-ylacetate, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. It should be stored at room temperature in a cool, dry place, away from direct sunlight and heat sources. In case of spills, immediately contain the spill and clean it up using appropriate absorbent materials. For detailed safety information, refer to the Material Safety Data Sheet (MSDS) or Safety Data Sheet (SDS) for Ethyl 1H-pyrazol-3-ylacetate (CAS: 82668-50-6).