5-Amino-2-fluoroisonicotinic acid(CAS: 171178-43-1)

5-Amino-2-fluoroisonicotinic acid is a white crystalline powder with a molecular weight of approximately 209.13 g/mol. It is slightly soluble in water and has a pKa of about 3.1. This compound is known for its moderate reactivity with basic and acidic reagents, making it suitable for various synthetic applications. It is also stable under normal conditions but should be stored in a dry, cool place to prevent degradation.

5-Amino-2-fluoroisonicotinic acid is commonly synthesized via a two-step process. First, 2-fluoroisonicotinic acid is aminated using an amino group donor such as an amine or an amide. Commonly used solvents include DMF or DMSO. The second step involves the protection of the amino group, followed by deprotection to yield the desired compound. This method provides good selectivity and yield, making it a reliable route for synthesis.

5-Amino-2-fluoroisonicotinic acid finds applications in the pharmaceutical industry for drug synthesis, particularly in the development of new antiviral and antifungal agents. It is also used in the polymer industry for the modification of polymer properties and in the production of sensors for detecting specific chemical compounds. Additionally, it has potential applications in the semiconductor industry for use in certain chemical vapor deposition processes.

When handling 5-Amino-2-fluoroisonicotinic acid, it is important to use appropriate personal protective equipment (PPE), such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be handled with caution using appropriate absorbent materials. It is recommended to consult the Safety Data Sheet (SDS) for detailed information on proper handling and disposal procedures. Storage should be in a cool, dry place away from direct sunlight and heat sources.