3-Benzoyl-2-pyridinecarboxylic acid(CAS: 64362-32-9)

3-Benzoyl-2-pyridinecarboxylic acid is a crystalline solid with a molecular weight of approximately 248.24 g/mol. It has a low solubility in water (0.04 g/100 mL at 20°C) but is more soluble in organic solvents like ethanol and acetone. This compound is known for its high reactivity, particularly towards nucleophilic substitution and condensation reactions.

3-Benzoyl-2-pyridinecarboxylic acid can be synthesized through the condensation of 2-pyridinecarboxylic acid and benzoic anhydride in the presence of a Lewis acid catalyst like aluminum trichloride. The reaction is exothermic and yields a high purity product with good selectivity and moderate to high yield.

3-Benzoyl-2-pyridinecarboxylic acid is used in various industries, including pharmaceuticals, where it serves as an intermediate in the synthesis of certain drugs. It is also relevant in the manufacturing of polymers, sensors, and semiconductors due to its chemical reactivity and structural properties.

When handling 3-Benzoyl-2-pyridinecarboxylic acid (CAS: 64362-32-9), it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a laboratory coat. Work in a well-ventilated area or a fume hood to avoid inhalation. In case of a spill, immediately clean up using appropriate materials and follow the safety data sheet (SDS) for further instructions. Proper disposal of waste should be in accordance with local regulations.