Methyl 2-chloronicotinate(CAS: 40134-18-7)

Methyl 2-chloronicotinate is a solid with a crystalline form. Its molecular weight is approximately 171.68 g/mol. It has a low water solubility and is slightly soluble in organic solvents. Reactivity is moderate, showing some acidic behavior, and it is stable under normal conditions but can react with strong bases. It has a pungent odor and is used in various applications due to its chemical stability and reactivity.

Methyl 2-chloronicotinate is typically synthesized by chlorinating nicotinic acid with methylamine. The reaction is carried out in the presence of a catalyst such as aluminum chloride, resulting in a high yield. The reaction is selective, and the product is isolated by recrystallization. This process is efficient and can be scaled up for industrial production.

Methyl 2-chloronicotinate finds applications in the pharmaceutical industry as an intermediate for the synthesis of various drugs. It is also used in the polymer industry for the modification of polymers. Additionally, it is employed in the production of sensors and as a reagent in semiconductor manufacturing processes.

When handling Methyl 2-chloronicotinate, it is essential to wear appropriate personal protective equipment (PPE), including gloves and goggles. Store the compound in a fume hood to minimize inhalation risks. In case of a spill, avoid direct contact and clean up using appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for detailed information on handling and safety measures.