4-(Trifluoromethyl)nicotinamide(CAS: 158062-71-6)

4-(Trifluoromethyl)nicotinamide (CAS: 158062-71-6) is a crystalline white powder with a molecular weight of approximately 220.11 g/mol. It is slightly soluble in water and more soluble in organic solvents like methanol and acetonitrile. The compound is generally stable under normal conditions but can react with strong bases. It is used in various applications due to its chemical stability and reactivity.

4-(Trifluoromethyl)nicotinamide (CAS: 158062-71-6) can be synthesized by reacting 4-chloronicotinamide with a trifluoromethylating agent such as trifluoromethyl chloroformate in the presence of a base like pyridine. The reaction is typically carried out in anhydrous conditions to enhance yield and selectivity. This compound is synthesized using common laboratory techniques and is known for its good yield and purity.

4-(Trifluoromethyl)nicotinamide (CAS: 158062-71-6) is widely used in pharmaceuticals for the development of certain therapeutic agents. It is also utilized in the production of electronic materials, particularly in semiconductor fabrication, and in the manufacturing of certain polymers and sensors due to its unique chemical properties.

When handling 4-(Trifluoromethyl)nicotinamide (CAS: 158062-71-6), it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. The compound should be stored in a cool, dry place, away from direct sunlight and heat sources. In case of a spill, it should be cleaned up immediately using appropriate methods, and the area should be well-ventilated. Always consult the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures.