4-(4-Methoxyphenyl)-1-piperazinecarboxamide(CAS: 89026-59-5)

4-(4-Methoxyphenyl)-1-piperazinecarboxamide is a white to off-white crystalline solid with a molecular weight of approximately 264.34 g/mol. It is slightly soluble in water and more soluble in organic solvents like methanol and ethanol. Chemically, it is stable under normal conditions but may degrade at high temperatures or in the presence of strong acids or bases. It has a pKa of about 8.5, indicating basic properties.

4-(4-Methoxyphenyl)-1-piperazinecarboxamide is typically synthesized via a multi-step process involving the reaction of 4-methoxybenzamide with piperazine. Commonly, the synthesis involves the addition of piperazine to a solution of 4-methoxybenzamide in an appropriate solvent, followed by the use of a catalyst such as 4-(dimethylamino)pyridine (DMAP) to enhance the reaction. The yield is usually around 75-85%.

4-(4-Methoxyphenyl)-1-piperazinecarboxamide is primarily used in the pharmaceutical industry due to its potential pharmacological effects. It also finds applications in the polymer industry as a stabilizer and in the development of advanced materials. Additionally, it has potential uses in the production of sensors and semiconductors, though its exact role in these areas is less well-documented.

When handling 4-(4-Methoxyphenyl)-1-piperazinecarboxamide, it is important to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate absorbent materials. A safety data sheet (SDS) should be consulted for detailed safety information and emergency procedures.