Rociletinib(CAS: 1374640-70-6)

Rociletinib is a crystalline compound with a molecular weight of approximately 453.45 g/mol. It has a limited solubility in water, but is more soluble in organic solvents like methanol and DMSO. Rociletinib is known for its chemical stability under normal storage conditions, although it should be stored away from heat and direct sunlight. It reacts selectively with certain functional groups and is generally considered to have moderate reactivity under typical synthetic conditions.

Rociletinib is typically synthesized through multi-step organic synthesis involving key reactions such as alkylation, nucleophilic substitution, and condensation. The synthesis often requires the use of reagents like chlorides and amines, with the use of catalysts to improve selectivity and yield. The process involves careful control of reaction conditions to ensure product purity and yield.

Rociletinib is primarily used in the pharmaceutical industry for its role as an inhibitor of the Tropomyosin receptor kinase (Trk) family of tyrosine kinases. It has applications in the development of targeted cancer therapies. Rociletinib is not commonly used in other industries such as polymers, sensors, or semiconductors.

When handling Rociletinib, it is crucial to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. It should be stored in a well-ventilated area and handled in a fume hood to minimize exposure. In case of a spill, immediately clean up using appropriate absorbent materials and dispose of them according to local waste disposal regulations. For detailed safety information, refer to the Safety Data Sheet (SDS).