(2E)-1-(5-Hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(4-hydroxyphenyl)-2-propen-1-one(CAS: 52801-22-6)

The compound (2E)-1-(5-Hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(4-hydroxyphenyl)-2-propen-1-one (CAS: 52801-22-6) is a crystalline solid with a molecular weight of approximately 322.27 g/mol. It has a low solubility in water but is soluble in organic solvents like ethanol and dichloromethane. The compound is moderately reactive towards oxidizing agents but stable under normal conditions. It exhibits good spectroscopic properties and can be detected using UV-Vis and NMR spectroscopy.

(2E)-1-(5-Hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(4-hydroxyphenyl)-2-propen-1-one (CAS: 52801-22-6) is synthesized through a series of reactions involving coupling of a chromenone derivative with a phenol under basic conditions. Commonly, the synthesis involves the use of sodium hydride as a base, with a yield of up to 85%. The reaction is performed in a solvent like dimethylformamide (DMF) and the product is isolated by column chromatography.

(2E)-1-(5-Hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(4-hydroxyphenyl)-2-propen-1-one (CAS: 52801-22-6) is utilized in the pharmaceutical industry for its potential as a drug intermediate. It is also applicable in the production of organic pigments and as a component in sensors and semiconductors due to its unique structural properties.

When handling (2E)-1-(5-Hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(4-hydroxyphenyl)-2-propen-1-one (CAS: 52801-22-6), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Ensure the use of a fume hood during the handling or synthesis of the compound. In case of a spill, use absorbent material and dispose of according to laboratory waste protocols. Refer to the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.