How is (2E)-1-(5-Hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(4-hydroxyphenyl)-2-propen-1-one (CAS: 52801-22-6) typically synthesized?

(2E)-1-(5-Hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(4-hydroxyphenyl)-2-propen-1-one (CAS: 52801-22-6) is synthesized through a series of reactions involving coupling of a chromenone derivative with a phenol under basic conditions. Commonly, the synthesis involves the use of sodium hydride as a base, with a yield of up to 85%. The reaction is performed in a solvent like dimethylformamide (DMF) and the product is isolated by column chromatography.