2-Chloro-3,5-diiodopyridine(CAS: 856169-60-3)

2-Chloro-3,5-diiodopyridine is a crystalline solid with a molecular weight of approximately 433.9 g/mol. It has low water solubility and moderate solubility in organic solvents like DMSO and THF. The compound is relatively stable under inert conditions but can react with reducing agents. It is not flammable and has a melting point around 190-195°C.

2-Chloro-3,5-diiodopyridine can be synthesized through the iodination of 2-chloropyridine using iodine in the presence of a Lewis acid catalyst such as aluminum trichloride (AlCl3). The reaction provides good yield and selectivity, making it a viable method for preparing this compound.

2-Chloro-3,5-diiodopyridine finds application in the pharmaceutical industry for the synthesis of certain intermediates and drug candidates. It is also used in the field of materials science, specifically in the development of sensors and semiconductors, due to its unique chemical properties.

When handling 2-Chloro-3,5-diiodopyridine, it is essential to wear appropriate personal protective equipment (PPE) including gloves, lab coat, and goggles. Store the compound in a cool, dry place away from moisture and direct sunlight. Use a fume hood during handling to minimize inhalation risk. Always consult a safety data sheet (SDS) for detailed handling and emergency procedures.