N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-histidine(CAS: 116611-64-4)

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-histidine is a white to off-white solid with a molecular weight of approximately 522.4 g/mol. It has a low aqueous solubility and is highly reactive towards nucleophiles. This compound is typically crystalline and stable under normal conditions.

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-histidine is synthesized through a multi-step process involving the protection of the amino group of histidine, followed by coupling with fluoren-9-ylmethanol using a suitable coupling agent like HATU or EDC. The yield is generally high, and the reaction is selective.

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-histidine is primarily used in the pharmaceutical industry for the synthesis of peptide-based drugs. It also finds applications in the polymer industry for the preparation of functional polymers and in the semiconductor industry for use in organic electronic devices.

Handle N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-histidine in a fume hood to avoid inhalation. Wear gloves and eye protection. Store the compound in a cool, dry place away from direct sunlight. In case of spill, use appropriate PPE and follow standard safety procedures for chemical spills. Always consult the Safety Data Sheet (SDS) for detailed handling instructions.