5-Bromo-4-chloroquinazoline(CAS: 2148-38-1)

5-Bromo-4-chloroquinazoline is a white or off-white crystalline solid with a molecular weight of approximately 276.03 g/mol. It is slightly soluble in water but soluble in organic solvents like ethanol and acetone. It is moderately reactive, showing limited reactivity with common bases and reduced reactivity with acids. The compound is stable under normal conditions but should be stored in a dry, cool place away from direct sunlight.

5-Bromo-4-chloroquinazoline is typically synthesized via the bromination of 4-chloroquinazoline followed by quenching with a base. This process involves the use of bromine in the presence of a suitable solvent, such as acetic acid, and a phase transfer catalyst. The yield of the reaction is generally around 70-80%, with good selectivity towards the brominated product.

5-Bromo-4-chloroquinazoline is used in the pharmaceutical industry for the development of potential drug candidates, particularly in the field of oncology and immune modulation. It is also utilized in the synthesis of certain polymers and as a building block in the production of sensors and semiconductors.

When handling 5-Bromo-4-chloroquinazoline, wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Ensure that the work is conducted in a well-ventilated area or a fume hood. Keep the compound away from heat sources and direct sunlight. In the event of a spill, use appropriate containment and clean up using a non-flammable solvent. Refer to the Safety Data Sheet (SDS) for detailed emergency procedures.