How is 5-Bromo-4-chloroquinazoline (CAS: 2148-38-1) typically synthesized?

5-Bromo-4-chloroquinazoline is typically synthesized via the bromination of 4-chloroquinazoline followed by quenching with a base. This process involves the use of bromine in the presence of a suitable solvent, such as acetic acid, and a phase transfer catalyst. The yield of the reaction is generally around 70-80%, with good selectivity towards the brominated product.