2-(2H-1,2,3-Triazol-2-yl)benzoic acid(CAS: 1001401-62-2)

2-(2H-1,2,3-Triazol-2-yl)benzoic acid is a solid crystalline compound with a molecular weight of approximately 265.22 g/mol. It is slightly soluble in water but more soluble in organic solvents like ethanol and acetone. The compound is relatively stable under normal conditions but can react with strong bases to form sodium salts. It also shows reactivity towards amine compounds.

2-(2H-1,2,3-Triazol-2-yl)benzoic acid is typically synthesized through a multi-step process, including the formation of a triazole ring using 1,2,3-triazole, followed by coupling with benzoic acid. Common synthetic routes involve the use of palladium catalysts and may require protective groups for functional group compatibility. The overall yield is around 75-85%.

2-(2H-1,2,3-Triazol-2-yl)benzoic acid is primarily used in the pharmaceutical industry for the synthesis of various drug intermediates. It also finds applications in the polymer industry as a stabilizer and in the development of advanced materials. Additionally, it is utilized in sensor technology for detecting certain chemical species and in semiconductor manufacturing as a dopant.

When handling 2-(2H-1,2,3-Triazol-2-yl)benzoic acid, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbent materials and the area should be thoroughly rinsed. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.