2-Cyanoisonicotinic acid(CAS: 161233-97-2)

2-Cyanoisonicotinic acid is a white crystalline solid with a molecular weight of approximately 191.15 g/mol. It has a high melting point of 234-236°C and is slightly soluble in water. Chemically, it is reactive towards bases and is a potent Lewis acid, often used in organic synthesis and as a catalyst in various reactions.

2-Cyanoisonicotinic acid can be synthesized by the reaction of nicotinic acid with cyanogen chloride. The yield is around 85%, with the reaction being carried out in a suitable solvent such as ethanol. Palladium catalysts are often used to increase selectivity and yield. The product is then purified by recrystallization from a suitable solvent.

2-Cyanoisonicotinic acid is used in the pharmaceutical industry for the synthesis of certain drugs, as a Lewis acid catalyst in organic synthesis, and in the development of sensors and semiconductors. It is also utilized in the polymer industry for the modification of polymer properties and in analytical chemistry for developing new reagents and detection methods.

When handling 2-Cyanoisonicotinic acid, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Store it in a cool, dry place away from incompatible materials. In case of a spill, use appropriate spill response materials and ensure proper disposal. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.