5-Nitro-1H-pyrazole(CAS: 26621-44-3)

5-Nitro-1H-pyrazole is a crystalline solid with a molecular weight of approximately 141.07 g/mol. It has a melting point of 220-222°C and is slightly soluble in water. This compound is known for its reactivity, particularly towards nucleophilic substitution and reduction reactions.

5-Nitro-1H-pyrazole can be synthesized through the nitration of 1H-pyrazole using nitric acid in the presence of sulfuric acid as a catalyst. The reaction typically yields 5-Nitro-1H-pyrazole in good to high selectivity with a yield of around 75-85%.

5-Nitro-1H-pyrazole is primarily used in the pharmaceutical industry for the synthesis of various drugs, particularly those involving nitrogen-containing heterocycles. It is also used in the polymer industry as a precursor for the synthesis of advanced materials and in the semiconductor industry for the development of electronic devices.

When handling 5-Nitro-1H-pyrazole, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. This compound should be handled in a well-ventilated area or a fume hood due to its potential for respiratory irritation. In case of a spill, use appropriate spill cleanup procedures and handle under a fume hood. Always refer to the Safety Data Sheet (SDS) for detailed information on handling and safety measures.