5-Iodo-2-(trifluoromethyl)pyridine(CAS: 873107-98-3)

5-Iodo-2-(trifluoromethyl)pyridine is a crystalline solid with a molecular weight of approximately 319.03 g/mol. It has poor water solubility but is soluble in common organic solvents such as dichloromethane and acetonitrile. This compound is less reactive than its chlorine or bromine analogs but can undergo redox reactions under appropriate conditions. It is a potent electrophile and can participate in various electrophilic aromatic substitution reactions.

5-Iodo-2-(trifluoromethyl)pyridine is typically synthesized by the iodination of 2-(trifluoromethyl)pyridine with iodine in the presence of a Lewis acid catalyst such as aluminum chloride. The reaction is performed in a solvent like dichloromethane and yields a high purity product with good selectivity and moderate to high yield depending on the reaction conditions.

5-Iodo-2-(trifluoromethyl)pyridine is primarily used in the pharmaceutical industry for the synthesis of intermediates and drug candidates. It is also used in the polymer industry for the modification of polymers, and in the semiconductor industry for the production of organic semiconductors. It is also explored for its application in sensors and as a reagent in organic synthesis.

When handling 5-Iodo-2-(trifluoromethyl)pyridine, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. This compound should be handled in a well-ventilated fume hood to minimize inhalation risks. Spills should be cleaned up with care using appropriate tools and materials, and the area should be flushed with water. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage guidelines.