(2-Bromo-5-chloro-4-pyridinyl)boronic acid(CAS: 1072952-51-2)

(2-Bromo-5-chloro-4-pyridinyl)boronic acid is a crystalline solid with a molecular weight of approximately 271.04 g/mol. It has a low solubility in water but is soluble in common organic solvents. This compound exhibits moderate reactivity in typical boronate esterification reactions. It is used in various synthetic chemistry applications due to its reactivity and specific functional groups.

(2-Bromo-5-chloro-4-pyridinyl)boronic acid can be synthesized via the reaction of 2-bromo-5-chloro-4-pyridine with boronic acid. Commonly, this is done using standard conditions with catalysis by a palladium complex, achieving good yield and selectivity. The reaction is typically performed under inert atmosphere to prevent side reactions.

(2-Bromo-5-chloro-4-pyridinyl)boronic acid is utilized in the pharmaceutical industry for the synthesis of bioactive compounds, as well as in the polymer industry for modifying the properties of polymers. It is also employed in the development of sensor materials and semiconductors due to its unique chemical properties.

When handling (2-Bromo-5-chloro-4-pyridinyl)boronic acid, wear appropriate personal protective equipment (PPE), including gloves and safety goggles, due to its potential for skin and eye irritation. Store in a cool, dry place away from direct sunlight and heat sources. Use a fume hood during synthesis and disposal. Always consult the safety data sheet (SDS) for detailed information on handling and disposal.