4-Acetylbenzonitrile(CAS: 1443-80-7)

4-Acetylbenzonitrile (CAS: 1443-80-7) is a colorless to white crystalline solid with a molecular weight of 148.15 g/mol. It is slightly soluble in water but freely soluble in organic solvents like ethanol and acetone. Chemically, it is moderately reactive, showing some electrophilic character. It has a melting point of 53-55°C and a boiling point of 218°C.

4-Acetylbenzonitrile (CAS: 1443-80-7) is commonly synthesized by acetylation of benzonitrile under acidic conditions. The reaction usually involves benzonitrile, acetic anhydride, and concentrated sulfuric acid as a catalyst. The yield is typically around 70-75% with good selectivity towards the acetylation product.

4-Acetylbenzonitrile (CAS: 1443-80-7) is used in the pharmaceutical industry for the synthesis of certain drugs, as well as in the polymer industry for specific applications. It is also utilized in the production of sensors and semiconductors due to its unique chemical properties.

When handling 4-Acetylbenzonitrile (CAS: 1443-80-7), it is essential to use proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be stored in a cool, dry place away from direct sunlight and flammable materials. In case of spill, use appropriate laboratory safety procedures and refer to the Safety Data Sheet (SDS). Fume hoods should be used during handling to minimize exposure.