2-Amino-4-methoxyphenol hydrochloride (1:1)(CAS: 32190-97-9)

2-Amino-4-methoxyphenol hydrochloride (CAS: 32190-97-9) is a crystalline solid with a molecular weight of approximately 211.7 g/mol. It has a pKa of around 1.8, indicating it is a strong acid. The compound is slightly soluble in water and ethanol. It exhibits good solubility in organic solvents like dichloromethane and acetonitrile. Chemically, it is a hydroxy phenol derivative with aminomethoxy functionality, making it reactive towards nucleophiles and electrophiles.

2-Amino-4-methoxyphenol hydrochloride is usually synthesized by the reaction of 4-methoxyphenol with hydrochloric acid or anhydrous hydrogen chloride. The synthesis involves the substitution of the hydroxyl group with a chloride ion, followed by the hydrolysis of the amino group to form the corresponding hydrochloride salt. Common solvents for this reaction include acetonitrile or dichloromethane. The reaction is typically carried out at room temperature with good yield and selectivity.

2-Amino-4-methoxyphenol hydrochloride (CAS: 32190-97-9) is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various drug candidates. It is also utilized in the polymer industry for the development of functional polymers with specific chemical properties. Additionally, it can be employed in the production of sensors and semiconductors due to its unique chemical reactivity and molecular structure.

When handling 2-Amino-4-methoxyphenol hydrochloride (CAS: 32190-97-9), it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. The compound should be stored in a sealed container in a cool, dry place away from direct sunlight. It should be handled in a well-ventilated area or in a fume hood due to its potential volatility and reactivity. In case of a spill, it should be handled according to the Material Safety Data Sheet (MSDS) guidelines, and the area should be thoroughly cleaned to prevent environmental contamination. Always refer to the latest MSDS for detailed safety information.