4,6-Dimethoxy-2-methylpyrimidine(CAS: 13566-48-8)

4,6-Dimethoxy-2-methylpyrimidine is a white crystalline solid with a molecular weight of approximately 198.15 g/mol. It has a solubility of about 1.5 g/L in water and is relatively insoluble in organic solvents. Chemically, it is moderately reactive, particularly with nucleophiles. It is stable under normal conditions but should be stored away from moisture and heat.

4,6-Dimethoxy-2-methylpyrimidine is commonly synthesized via the reaction of 2-methylpyrimidine with methanol under acidic conditions. The synthesis involves the methylation of the pyrimidine at the 2, 4, and 6 positions, with high selectivity and good yield. The process often uses catalytic amounts of acid like hydrochloric acid or sulfuric acid.

4,6-Dimethoxy-2-methylpyrimidine is used in various industries, including pharmaceuticals, where it serves as a precursor in the synthesis of drugs. It is also utilized in the polymer industry for the development of specialized polymers, and in the chemical industry for the production of dyes and other organic compounds.

When handling 4,6-Dimethoxy-2-methylpyrimidine, it is important to use appropriate personal protective equipment (PPE) such as gloves and safety goggles. It should be used in a well-ventilated area or in a fume hood. In case of a spill, it should be cleaned up using absorbent materials and the area should be well ventilated. Always refer to the Safety Data Sheet (SDS) for detailed handling and safety information.