2'-Deoxy-5'-O-trityluridine(CAS: 14270-73-6)

2'-Deoxy-5'-O-trityluridine is a white crystalline solid with a molecular weight of approximately 432.45 g/mol. It has a solubility in water of 0.5 mg/mL. The compound is relatively stable under neutral conditions but may react with strong acids or bases. It is commonly used in organic synthesis and nucleic acid research.

2'-Deoxy-5'-O-trityluridine is synthesized by tritylation of 2'-deoxyuridine. The reaction involves the use of a trityl chloride reagent and is typically carried out under anhydrous conditions. The yield is usually around 70-80% with good selectivity. The reaction is catalyzed by a strong base, such as pyridine or triethylamine.

2'-Deoxy-5'-O-trityluridine is primarily used in pharmaceutical and biochemical research. It is an important intermediate in the synthesis of nucleosides and nucleotides, which are crucial for drug development and in vitro diagnostics. It is also used in the production of oligonucleotides for gene therapy and antisense technology.

Proper handling of 2'-Deoxy-5'-O-trityluridine requires the use of personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a cool, dry place away from moisture and heat sources. It should be handled in a well-ventilated area or fume hood. In case of accidental spill, avoid contact with skin and eyes, and clean up with appropriate absorbent material. Consult the Safety Data Sheet (SDS) for further information on handling and disposal.