2-Methyl-4-(trifluoromethyl)phenylboronic acid(CAS: 957034-45-6)

2-Methyl-4-(trifluoromethyl)phenylboronic acid has a crystalline form with a molecular weight of approximately 231.11 g/mol. It is slightly soluble in water but more soluble in organic solvents like methanol and dichloromethane. This compound is reactive towards various nucleophiles and can be used as a boronic acid in cross-coupling reactions.

2-Methyl-4-(trifluoromethyl)phenylboronic acid is typically synthesized via a Suzuki-Miyaura coupling reaction. The synthesis involves the reaction of 2-methyl-4-(trifluoromethyl)phenylboronic pinacol ester with a boronate ester in the presence of a palladium catalyst, such as Pd(PPh3)4, and a base like sodium carbonate or potassium carbonate.

2-Methyl-4-(trifluoromethyl)phenylboronic acid finds application in the pharmaceutical industry for drug synthesis, particularly in the development of novel drug candidates. It is also used in the synthesis of polymers and in the preparation of functional materials for sensors and semiconductors.

When handling 2-Methyl-4-(trifluoromethyl)phenylboronic acid, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work should be conducted in a fume hood to minimize inhalation risks. Spills should be cleaned up immediately and handled according to the safety data sheet (SDS).