(4-Fluorophenyl)acetyl chloride(CAS: 459-04-1)

(4-Fluorophenyl)acetyl chloride is a white crystalline solid with a molecular weight of approximately 206.64 g/mol. It is slightly soluble in water but soluble in common organic solvents like ethanol and acetone. Chemically, it is highly reactive, particularly with nucleophiles, and can undergo various substitution reactions under appropriate conditions.

(4-Fluorophenyl)acetyl chloride can be synthesized by the reaction of 4-fluorophenylacetic acid with thionyl chloride in the presence of a solvent such as ethanol or dioxane. The process typically involves heating to around 80°C and can yield up to 80% conversion with good selectivity.

The compound is primarily used in pharmaceuticals for the synthesis of various drug intermediates. It also finds applications in polymer chemistry, where it serves as a monomer or crosslinking agent, and in the production of sensors and semiconductors for its reactivity and functional groups.

Handling (4-Fluorophenyl)acetyl chloride requires appropriate Personal Protective Equipment (PPE) including gloves, goggles, and a lab coat. Work should always be conducted in a fume hood. Spills should be handled by neutralizing with a basic solution and disposing of the residue according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed information on safe handling and storage.